Cell Biology and Neuroscience
Trying to understand the cellular and synaptic substrates underlying innocuous touch perception by elucidating the functional organization of sensory neurons in mouse hairy skin and uncovering the neural codes of touch perception in the spinal cord dorsal horn.
Molecular mechanisms underlying sensory and cognitive function in mouse models of human diseases. The lab is interested in understanding how mutations in chromatin remodeling proteins results in hyperactivity and circling behavior in mutant mice. Identifying transcriptome changes in affected neurons by deep sequencing will help us understand how the activity and development of these neurons have been altered. Our goal is to bridge the molecular changes in neurons to the abnormal behavior observed in these mouse models.
Sensory processing, decision-making, and neural plasticity in mice. Record and manipulate specific neurons and neural circuits as mice perform learned tactile behaviors to understand sensory-guided decision-making from the synaptic to the network levels. We are also interested in how brain injury and neurological disorders impact neuronal activity and behavior.